Welcome to AcrBank

CRISPR is a tool that is widely used for gene editing. However, unexpected off-target effects may occur as a result of long-term nuclease activity. Anti-CRISPR proteins, which are powerful molecules that inhibit the CRISPR-Cas system, may have the potential to promote better utilization of the CRISPR system in gene editing, especially for gene therapy. Additionally, more in-depth research on these proteins would help researchers to better understand the co-evolution of bacteria and phages. Therefore, it is necessary to collect and integrate data on various types of anti-CRISPR proteins. Data on these proteins were manually gathered through text mining and data screening of the literatures. We then constructed anti-CRISPRdb: this is the first online resource for organizing these proteins. It enables easy browsing of the anti-CRISPRs that have been published. It contains the available protein sequences, DNA sequences, coding regions, source organisms, taxonomy, virulence, and protein interactors and the corresponding three-dimensional structures.

Citation:Chuan Dong, Ge-Fei Hao, Hong-Li Hua, Shuo Liu, Abraham Alemayehu Labena, Guoshi Chai, Jian Huang, Nini Rao, Feng-Biao Guo; Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteins, Nucleic Acids Research, gkx835, https://doi.org/10.1093/nar/gkx835

collections :

I-B(1)

I-C(17)

I-D(52)

I-E(232)

I-F(779)

II-A(2396)

II-C(155)

III-B(1)

V-A(28)

VI-A(7)

VI-B(24)

Verified(125)

Literature(1253)

Predict(2304)

3Dstructure(345)